Lead by 11 points from Josie McLean and 10 from Ava Jones, Nickerson topped Halstead in a low scoring contest 40-29 Friday night.
The loss is just the third on the season for Halstead as Nickerson improved to 13-2.
Nickerson's size kept Halstead to single digit scoring in three of the four quarters, setting the tone in a game that saw just two Dragons score for the entirety of the contest.
Karenna Gerber lead all scorers with 17 while Kaleigh O'Brien added 12 in the loss.
The win for Nickerson puts them in sole possession of the top spot in Class 4A, sitting a half-game up on Circle. The Panthers take on Pratt next week before hosting Haven, the team responsible for both of their losses this season.
Halstead will try to bounce back with road games at Hillsboro and Hoisington.